Can HDL help with longevity?

HDL cholesterol is often called 'good' cholesterol and is associated with lower cardiovascular disease risk in observational studies, which could indirectly support longevity. However, randomized trials and Mendelian randomization studies show that simply raising HDL levels (e.g., via drugs or certain genetic variants) does not consistently reduce cardiovascular events or extend lifespan. The evidence for a direct causal role of HDL in longevity is mixed: while high HDL is a marker of a healthy lifestyle, isolated HDL elevation lacks strong interventional support. Caveat: HDL is a useful biomarker but not a standalone longevity target. A holistic approach focusing on diet, exercise, and overall metabolic health is likely more effective.