Is ADH1B useful for longevity?

The ADH1B gene variant (especially rs1229984, which slows alcohol metabolism) is associated with lower alcohol consumption and reduced risk of alcohol-related diseases such as liver cirrhosis and certain cancers. This may indirectly contribute to increased longevity. However, ADH1B is not a direct longevity gene. Evidence comes from observational studies linking the variant to lower drinking levels and better health outcomes. Effect sizes vary by population and are not consistent across all ethnic groups. For individual longevity prediction, ADH1B alone is insufficient; lifestyle, environment, and many other genetic factors are more influential. Caveat: the same variant can also lead to higher acetaldehyde exposure, which may increase esophageal cancer risk in some individuals. Overall, the utility for longevity is moderate and indirect.