What to watch with CYP1A2 and Langlebigkeit?

CYP1A2 encodes the enzyme that metabolizes caffeine. Variants determine whether you are a 'fast' or 'slow' metabolizer. Some studies suggest slow metabolizers who drink high amounts of coffee may have a slightly increased risk of cardiovascular events, which could indirectly affect longevity. However, direct evidence linking CYP1A2 to lifespan is weak and inconsistent. The effect is polygenic and heavily confounded by lifestyle. A single gene test is not clinically actionable for longevity. Beware of overblown marketing claims. Evidence: mechanistic/mixed.