Evidence check: LCT in the context of Langlebigkeit

The link between LCT (lactase persistence) and longevity is not scientifically robust. Variants like rs4988235 determine adult lactose digestion. In dairy-farming populations, lactase persistence may provide nutritional benefits (e.g., calcium intake, bone health) that could indirectly support longevity. However, evidence is mixed: some studies show higher bone density, others suggest increased cancer risk (e.g., ovarian). Direct lifespan effects are not consistently replicated. Consumer DNA tests often overstate the relevance. Evidence level: mixed/unclear – based on population genetics and observational data, not causal longevity trials. Caveat: single genes rarely determine lifespan; lifestyle and environment dominate.