How are COMT and skin aging related?

COMT (catechol-O-methyltransferase) is involved in metabolizing catecholamines and estrogens. The common Val158Met variant (rs4680) alters enzyme activity: the Met allele reduces activity, potentially affecting estrogen levels and oxidative stress. Since estrogens influence collagen synthesis and skin elasticity, a link to skin aging is plausible. However, the evidence is weak. No robust clinical trials directly connect COMT variants to skin aging. Existing data come from mechanistic or small observational studies. Skin aging is multifactorial—UV exposure, diet, lifestyle, and many genes play larger roles. A single COMT variant likely has a negligible effect. Thus, using COMT genotyping to predict or guide anti-aging skincare is not evidence-based. Consumers should be cautious of marketing claims that overstate such genetic associations. Further research is needed before any clinical recommendation can be made.