Myths vs facts: CYP2D6 and Haut

CYP2D6 is a liver enzyme primarily involved in drug metabolism, not directly in skin health. Myths claim that certain CYP2D6 variants cause acne, premature aging, or pigmentation issues. Facts: No robust human studies show a direct causal link between CYP2D6 genotypes and skin conditions. Weak associations come from tamoxifen studies (a drug metabolized by CYP2D6) where metabolites may indirectly affect skin reactions. Metabolism of endogenous steroid hormones or omega-3s has been speculated, but effects are small and polygenic. Consumer DNA tests marketing CYP2D6 as a 'skin gene' greatly overstate the evidence. Skin aging is driven by UV exposure, lifestyle, and collagen metabolism – not a single CYP variant. Safety note: CYP2D6 status is clinically relevant for dosing many drugs (e.g., antidepressants, beta-blockers), but not for skincare. Don't be misled by marketing: a CYP2D6 test tells you nothing about your skin health.