What role does APOE play in longevity?

APOE (Apolipoprotein E) is a key regulator of lipid metabolism and comes in three common variants: ε2, ε3, and ε4. The ε4 allele (rs429358) is the strongest known genetic risk factor for Alzheimer's disease and also increases risk for cardiovascular disease, both of which can reduce longevity. However, APOE4 is not deterministic; many carriers live into old age, especially with a healthy lifestyle. The ε2 variant is associated with a modest protective effect. Evidence comes mainly from GWAS and large observational studies. Caveat: a DNA test alone cannot diagnose or predict longevity. MyBody-X offers APOE testing, but results should be interpreted alongside lifestyle, family history, and medical advice. A Mediterranean diet, regular exercise, and cognitive engagement may help mitigate risks. The predictive power for individual lifespan is limited due to polygenic and environmental influences.