Is Leaky Gut Test useful for gut health?

The usefulness of a 'Leaky Gut' test for gut health is scientifically questionable. The term 'leaky gut' refers to a hypothetical syndrome of increased intestinal permeability, but there is no consensus on its clinical definition or validated diagnostic criteria. Most commercial tests measure markers like zonulin, actomyosin, or lipopolysaccharide-binding protein in stool or blood. Evidence for their reliability is weak: zonulin correlations with permeability are inconsistent, and no prospective studies show that test results improve health outcomes. These tests are often marketed directly to consumers with exaggerated claims. A positive result may lead to unnecessary restrictive diets or supplements without proven benefit. For genuine gastrointestinal issues (e.g., IBS, celiac disease), established methods like the lactulose-mannitol test or endoscopy with biopsy remain the gold standard. Personalized medicine in this area lacks robust evidence. Conclusion: The test is not recommended for the general population; its clinical utility is unproven, and consumers should be wary of marketing hype.