When is Gluten Genetik actually useful?

Gluten genetics (HLA-DQ2/HLA-DQ8) is useful primarily when celiac disease is suspected but not yet confirmed. A negative result rules out celiac with high probability (>99% negative predictive value). However, a positive result does not diagnose celiac disease – many carriers never develop it. Clinical confirmation via serology and biopsy is essential. For non-celiac gluten sensitivity (NCGS), genetic testing has no proven utility; diagnosis relies on elimination diets and symptom tracking. Be cautious: some companies market gluten genetics as a broad solution for digestive issues, but evidence for NCGS is weak. In summary, the test is valuable for ruling out celiac disease, but it should not replace medical evaluation. Evidence: human-strong (for celiac), marketing/unclear (for NCGS).