What to watch with tTG IgA and longevity?

The question about tTG IgA and longevity concerns the link between celiac disease screening and overall health. tTG IgA (tissue transglutaminase IgA) is the primary serological marker for celiac disease, an autoimmune condition that, if untreated, can lead to chronic inflammation, malabsorption of nutrients (iron, vitamin D, B12, folate), and increased risk of osteoporosis, lymphoma, and other comorbidities. Early diagnosis and a gluten-free diet can reduce these risks, potentially improving life expectancy. However, evidence for a direct effect on longevity in the general population is weak; most studies focus on celiac patients. The provided context contains no specific information on tTG IgA or longevity. Therefore, this answer is based on general medical knowledge. Caution: a positive tTG IgA test should be confirmed by duodenal biopsy before starting a gluten-free diet. Evidence is rated as 'practice' (general medical practice).