Leaky Gut Test: which supplements make sense?

The question of which supplements make sense for 'leaky gut' is scientifically controversial. Leaky gut refers to increased intestinal permeability, linked to various conditions but not a recognized clinical diagnosis. Direct-to-consumer tests for leaky gut are generally unvalidated. Commonly recommended supplements like L-glutamine, zinc, curcumin, or probiotics have shown some positive effects on gut barrier function in studies, but mostly in specific patient groups (e.g., IBS, IBD). Evidence for general use in healthy individuals is weak. L-glutamine (5–10 g/day) may support barrier function, but high doses carry risks. Zinc (15–30 mg/day) aids cell regeneration, but excess can cause copper deficiency. Probiotics like Lactobacillus rhamnosus GG or Bifidobacterium lactis may strengthen tight junctions, but effects are strain-specific. Without medical evaluation and targeted diagnostics (e.g., lactulose-mannitol test), supplementation is not advisable. MyBody-X tests do not provide a direct leaky gut diagnosis. Evidence: mixed/practice. Safety note: consult a physician if intestinal disease is suspected.