Is BDNF useful for skin aging?

BDNF (Brain-Derived Neurotrophic Factor) is primarily known for its role in neuronal health and plasticity. In skin, BDNF is expressed by keratinocytes, fibroblasts, and melanocytes, and has been implicated in wound healing, melanocyte survival, and possibly skin aging. Some in vitro studies suggest BDNF may promote collagen synthesis and reduce oxidative stress. However, there are no robust human clinical trials demonstrating a direct anti-aging effect on skin. The evidence is largely mechanistic. Direct-to-consumer tests claiming BDNF as a biomarker for skin aging are not supported by strong human data. For improving skin health, proven strategies like sun protection, balanced nutrition, and moisturizing remain the gold standard. BDNF is an intriguing but not yet actionable target for skin anti-aging.