The FTO gene is strongly associated with body weight regulation; certain variants increase the risk of overweight and obesity. Since elevated BMI can impair fertility in both women (e.g., PCOS, anovulation) and men (e.g., reduced sperm quality), there is an indirect effect. Some studies suggest direct influences of FTO variants on reproductive processes like oocyte maturation or sperm function, but the evidence is moderate and not conclusive. MyBody-X can test FTO variants as part of a DNA analysis, but the clinical relevance for fertility is limited. Results should not be used as the sole basis for family planning decisions. Lifestyle factors such as diet, exercise, and weight management are more impactful. For specific fertility concerns, genetic counseling is recommended. Note: This test does not replace medical diagnosis.
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