Myths vs facts: CYP2D6 and Fruchtbarkeit

CYP2D6 is a drug-metabolizing enzyme involved in processing estrogens and serotonin, but there is no robust evidence directly linking CYP2D6 variants to fertility. Myths often arise from indirect associations: CYP2D6 metabolizes tamoxifen (used in breast cancer) and some antidepressants, which can affect hormone balance or libido. However, this does not mean a specific CYP2D6 genotype predicts fertility in healthy individuals. The evidence is mechanistic and extrapolated, not based on clinical fertility trials. A standalone CYP2D6 genetic test is not appropriate for fertility assessment. Anyone experiencing real fertility issues should consult a specialist rather than rely on direct-to-consumer genetic tests.