Myths vs facts: CRP Entzündung and allergy

CRP (C-reactive protein) is an acute-phase reactant that rises during systemic inflammation—such as infections, autoimmune diseases, or tissue injury. In the context of allergies, the evidence is mixed. Allergic reactions are primarily IgE-mediated and cause localized inflammation (e.g., in the nose, airways, or skin), which does not necessarily elevate systemic CRP. Some studies report mild CRP increases in seasonal allergic rhinitis or asthma, but the effect is small and not diagnostically useful. Marketing claims that a CRP test can detect or monitor allergies are misleading. High-sensitivity CRP (hs-CRP) is used for cardiovascular risk assessment, not allergy. Fact: CRP is a non-specific marker; a normal CRP does not rule out allergy, and an elevated CRP does not confirm it. The evidence is mixed—strong for general inflammation, but weak for allergy-specific diagnostics. For suspected allergy, specific IgE tests or provocation tests are indicated.