What role does hsCRP play in Müdigkeit?

High-sensitivity C-reactive protein (hsCRP) is a well-established biomarker of systemic inflammation. Chronically elevated levels (≥2 mg/L) are associated with increased cardiovascular risk, and there is evidence that low-grade inflammation can contribute to fatigue – for example in chronic fatigue syndrome, autoimmune conditions, or metabolic disorders. However, hsCRP is not a specific fatigue marker: many individuals with normal hsCRP report exhaustion, and not everyone with elevated hsCRP feels fatigued. The evidence for a direct causal role of hsCRP in fatigue is moderate and largely based on observational studies. In clinical practice, hsCRP is not used alone to evaluate fatigue but as part of a broader workup (e.g., complete blood count, thyroid function, iron status, vitamin D). An isolated high hsCRP should be interpreted by a physician, as it can be influenced by infections, smoking, or obesity. For consumers: a DNA test for IL-6 variants (e.g., rs1800795) does not replace an hsCRP blood test – the blood measurement remains the gold standard. Persistent fatigue warrants medical evaluation.