Myths vs facts: SHBG and Haut

SHBG (sex hormone-binding globulin) controls the balance of free testosterone and estrogen. Myth: 'Low SHBG directly causes acne or skin aging.' Fact: Low SHBG increases free androgens, which can stimulate sebum production and acne in genetically susceptible individuals. However, SHBG is only one marker – insulin resistance, thyroid function, and liver health also strongly influence skin. Myth: 'SHBG levels can be raised with specific supplements.' Fact: SHBG is primarily modulated by lifestyle (diet, exercise, weight) and hormonal status; direct supplementation lacks evidence. Genetic tests for SHBG variants (e.g., rs6259) have small, polygenic effects and are not diagnostic for skin conditions. A blood SHBG measurement can be useful in a broader hormone panel, but not as a standalone skin predictor. Evidence: mechanistic and observational; no clinical validation for skin-specific claims.