Is MY FOODBOOK useful for fertility?

MY FOODBOOK is a direct-to-consumer (DTC) nutrigenetic test claiming to provide personalized dietary advice. For fertility, there is no robust evidence that such tests offer clinically meaningful benefit. The underlying genetics (e.g., FTO, MTHFR, CYP19A1) have only very small effects on hormone levels or metabolic pathways relevant to fertility. Trials like POINTS-RCT (PMID 37813841) and meta-analyses show no advantage of genotype-matched diets. Professional bodies (Academy of Nutrition, AHA) advise against routine testing. For fertility, established hormone measurements (estradiol, progesterone) timed to cycle phase, along with lifestyle factors (diet, weight, stress), are far more relevant. A DTC test cannot determine cycle phase or replace clinical hormone analysis. Evidence is rated 'mixed/unclear' – use with caution.