How are VKORC1 and Müdigkeit related?

The relationship between VKORC1 and fatigue (Müdigkeit) is not well established. VKORC1 encodes vitamin K epoxide reductase, a key enzyme in the vitamin K cycle that affects blood coagulation and bone metabolism. It is primarily known for its role in warfarin sensitivity: variants like rs9923231 alter enzyme activity and thus anticoagulation. Fatigue is not a direct genetic effect of VKORC1; it may arise indirectly from medication side effects or vitamin K deficiency. The provided context contains no specific studies linking VKORC1 to fatigue. Therefore, the evidence is unclear. Consumers should not rely on DNA tests to explain fatigue; instead, medical evaluation (blood work, thyroid, sleep quality) is recommended.