Is BDNF useful for sleep?

BDNF (Brain-Derived Neurotrophic Factor) is a protein crucial for neuronal plasticity and survival. Some studies suggest it may play a role in sleep regulation, e.g., by influencing circadian rhythms or sleep architecture. However, the evidence is mostly mechanistic or from animal studies; clear clinical recommendations for humans are lacking. Consumer DNA tests for BDNF are often marketing-driven and not suitable as a basis for sleep optimization. Validated biomarkers (e.g., melatonin, cortisol) or sleep logs are more informative. Be cautious about overinterpreting genetic test results.