Is COMT useful for skin aging?

Whether COMT is useful for skin aging is not well supported by current evidence. COMT (catechol-O-methyltransferase) degrades catecholamines and estrogens. Some hypotheses suggest that COMT variants (e.g., rs4680, Val158Met) may influence estrogen metabolism and thus skin elasticity or collagen, but the evidence is mostly mechanistic or from small, unreplicated association studies. Skin aging is multifactorial—UV exposure, lifestyle, hormonal status, and other genes (e.g., MC1R, MMPs) are more relevant. A DNA test for COMT alone cannot provide clinically actionable information on skin aging. Anyone concerned about premature skin aging should see a dermatologist. Evidence level: unclear.