Myths vs facts: VKORC1 and longevity

VKORC1 encodes vitamin K epoxide reductase, a key enzyme in the vitamin K cycle. It is best known for its role in warfarin sensitivity. Some consumer DNA tests claim that VKORC1 variants are linked to longevity, because vitamin K influences blood clotting, bone metabolism, and vascular health. However, the scientific evidence for a direct connection between VKORC1 polymorphisms and human longevity is weak. No large GWAS have identified VKORC1 as a significant longevity marker. The proposed effects are purely mechanistic and indirect (e.g., via vitamin K status and arterial calcification). Moreover, vitamin K status is heavily influenced by diet and gut microbiome. A DNA test alone cannot predict lifespan. Claims that VKORC1 is a 'longevity gene' are more marketing than evidence-based science. Clinically, VKORC1 testing (e.g., rs9923231) is relevant for warfarin dosing, not for longevity. Lifestyle factors such as exercise, diet, and smoking cessation have a far greater impact on lifespan.