How are Ferritin Eisenmangel and longevity related?

The relationship between ferritin (iron deficiency) and longevity is complex and indirect. Ferritin is the main iron storage protein. Low ferritin (iron deficiency) can lead to anemia, fatigue, impaired immune function, and cognitive decline – all of which can reduce quality of life and potentially shorten lifespan. Conversely, high ferritin (iron overload) is associated with oxidative stress, inflammation, and chronic diseases such as cardiovascular disease, diabetes, and cancer, which can also reduce longevity. The optimal ferritin level for maximum lifespan likely lies in the mid-normal range. However, evidence for a direct causal link between ferritin and human longevity is limited. Most data come from observational studies showing associations but not causality. Ferritin is also an acute-phase reactant, meaning inflammation can elevate levels independently of iron stores, complicating interpretation. A DNA test for iron metabolism genes (e.g., HFE) can indicate predisposition but does not replace blood measurement. For longevity, a balanced iron status is more important than any single biomarker. The evidence is rated as human-moderate.