Myths vs facts: COMT and Langlebigkeit

The role of the COMT gene (catechol-O-methyltransferase) in longevity is often overstated. Fact: COMT breaks down catecholamines (dopamine, adrenaline) and estrogens. The common SNP rs4680 (Val158Met) alters enzyme activity – slow Met carriers have higher baseline dopamine but reduced stress regulation. Myth: COMT directly determines lifespan. Evidence is weak. Association studies show small effects on cognition and stress resilience, but no robust link to all-cause mortality. MyBody-X DNA tests may include COMT variants, but clinical utility for longevity advice is low. Effects are heavily modulated by environment, diet, and lifestyle. A personalized approach should rely on validated biomarkers (e.g., inflammation, glucose) rather than COMT alone. Safety note: Do not initiate supplements or diets based solely on COMT status without medical supervision.