Is COMT useful for Wechseljahre?

COMT (catechol-O-methyltransferase) plays a role in estrogen metabolism. The common rs4680 (Val158Met) variant alters enzyme activity: the Met allele reduces activity, potentially leading to higher levels of catechol estrogens. During menopause (Wechseljahre), this could theoretically influence symptoms like hot flashes or mood, as well as estrogen-related disease risk. However, the evidence is mixed and effect sizes are modest. A standalone COMT DNA test is not clinically validated for guiding menopause management. Hormonal changes, lifestyle, and other genetic factors have greater impact. Currently, no guideline recommends adjusting hormone therapy or supplements based solely on COMT genotype. Be cautious of overhyped marketing claims. A holistic approach with a healthcare provider is more appropriate.