How are VKORC1 and Langlebigkeit related?

The relationship between VKORC1 and longevity is indirect and not supported by direct evidence. VKORC1 encodes vitamin K epoxide reductase, a key enzyme in blood coagulation and vitamin K metabolism. The variant rs9923231 (‑1639G>A) is the strongest known genetic predictor of warfarin dose requirements (p = 3e-181). A secondary association with body mass index (BMI) has been reported (p = 5e-28, beta = 0.027 units), but the effect is very small. Longevity could theoretically be influenced through cardiovascular health or vitamin‑K‑dependent processes (e.g., arterial calcification), but current GWAS data do not show a direct link. Evidence is limited to pharmacogenetics and a weak BMI association. Consumers should not infer any direct impact on lifespan from this gene.