Can HLA-DQ2 help with gut health?

HLA-DQ2 is a genetic risk factor for celiac disease, not a 'helper' for gut health. Carriers have an increased likelihood of developing an immune reaction to gluten, leading to intestinal inflammation and malabsorption. However, only about 2–5 % of HLA-DQ2-positive individuals actually develop celiac disease. The mere presence of the gene says little about current gut health. Testing for HLA-DQ2 can be useful in celiac diagnostics, but as a general gut health marker it is misleading. The evidence for its association with celiac disease is strong (human-strong), but there is no evidence that it actively helps gut health. Asymptomatic carriers do not need a gluten-free diet based solely on this genetic result. Comprehensive gut assessment (antibodies, biopsy) is essential.