How are Magnesium and longevity related?

Magnesium is involved in over 300 enzymatic reactions, including those regulating cortisol, sleep, and inflammation—all factors linked to aging. Some observational studies suggest higher magnesium intake is associated with lower all-cause mortality and better cardiovascular health, which could indirectly support longevity. However, direct causal evidence from randomized trials is limited. Consumer DNA or biomarker tests may claim links, but these are often based on weak associations. Magnesium deficiency is common in older adults and may accelerate age-related decline, but supplementation should be guided by blood levels and clinical context. Overall, the relationship is plausible but not firmly established.