What role does Selen play in Allergie?

Selenium is an essential trace element that acts as an antioxidant and immune modulator via selenoproteins (e.g., glutathione peroxidases). In allergies—particularly asthma, allergic rhinitis, and atopic dermatitis—oxidative stress and dysregulated immune responses play a role. Some observational studies suggest an association between low selenium status and increased allergy risk, but findings are inconsistent. Robust randomized controlled trials are lacking, so a causal role remains unproven. Genetic variants in selenoprotein genes (e.g., GPX1, SEPP1) may influence selenium utilization, but their clinical significance for allergies is unclear. MyBody-X DNA tests can detect such variants, but this does not constitute a diagnosis or treatment recommendation. Selenium supplementation for allergy prevention or treatment is not currently advised due to insufficient evidence and potential toxicity at high doses. If allergies are suspected, standard diagnostic methods (specific IgE, skin prick test) and medical consultation are essential.