Whether a CRP gene variant (e.g., rs3091244) can improve sleep is not scientifically established. CRP (C-reactive protein) is an inflammation marker that rises with stress, infection, or chronic disease. Some studies link elevated CRP to sleep disturbances, but causality is unclear: poor sleep can increase inflammation, and inflammation can disrupt sleep. MyBody-X DNA test includes rs3091244 in the CRP gene, but its clinical relevance for sleep is low. Sleep genetics is polygenic and involves many factors (e.g., COMT, BDNF, circadian genes) not covered in this test. A single CRP variant is insufficient for sleep optimization. Evidence: mechanistic/unclear. Safety note: Persistent sleep issues warrant medical evaluation; do not self-treat based on this marker alone.
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