What to watch with TSH Schilddrüse and Langlebigkeit?

TSH (thyroid-stimulating hormone) is a key indicator of thyroid function. Both markedly elevated and suppressed TSH levels are associated with increased mortality. However, population-based studies suggest that slightly elevated TSH (subclinical hypothyroidism) in older adults may correlate with extended lifespan, possibly due to reduced metabolic rate. The evidence is moderate and not causal. Importantly, TSH alone is insufficient; free T4, T3, thyroid antibodies, and individual risk factors (e.g., cardiovascular disease) must be considered. The genetic markers mentioned in the context (APOE, MTHFR) have no direct link to the thyroid axis. Self-optimizing TSH without medical supervision is not advisable, as both hyper- and hypothyroidism can damage organs over time. For longevity, established factors like diet, exercise, and stress management are more impactful than an isolated TSH target.