What role does FUT2 play in Blutzucker?

FUT2 encodes fucosyltransferase 2, which determines secretor status – whether ABH blood group antigens are secreted into bodily fluids like saliva and gastric juice. This status shapes gut microbiome composition and influences vitamin B12 absorption. Some studies report that non-secretors (e.g., carriers of rs601338) have slightly higher fasting glucose levels and a modestly increased risk of type 2 diabetes. The effect is small (around 0.1–0.2 mmol/L) and is outweighed by diet, physical activity, and other genetic factors. Evidence comes from GWAS and cohort studies, not from interventional trials. Therefore, a single FUT2 test is not clinically actionable for blood sugar management. The evidence level is human-moderate.