Can Selen help with Müdigkeit?

Selenium is an essential trace mineral critical for selenoproteins like glutathione peroxidase and iodothyronine deiodinases, which protect against oxidative stress and regulate thyroid hormone metabolism. In theory, selenium deficiency could contribute to fatigue via impaired thyroid function or increased oxidative damage. However, there is no strong human evidence that selenium supplementation reduces fatigue in individuals without a confirmed deficiency. Most evidence is mechanistic or derived from deficiency states. In well-nourished populations, selenium deficiency is uncommon; excess intake can be toxic (selenosis). Therefore, routine supplementation for fatigue is not supported by current science. If fatigue persists, a medical workup for iron, B12, thyroid, and sleep issues is more appropriate. MyBody-X tests do not directly measure selenium status; DNA or microbiome results cannot reliably indicate selenium needs.