A celiac test (e.g., tTG-IgA, HLA-DQ2/DQ8) is primarily used to diagnose celiac disease, an autoimmune condition triggered by gluten. Untreated celiac disease can impair sleep through several pathways: nutrient deficiencies (iron, vitamin D, B12) may cause restless legs syndrome or sleep apnea; chronic inflammation and abdominal discomfort disrupt sleep architecture; and associated anxiety or depression further worsen sleep quality. The test itself does not directly affect sleep—it only identifies the disease or risk. Following a positive diagnosis, a gluten-free diet may improve sleep in affected individuals, but evidence is limited to observational studies. Without clinical symptoms or risk factors, a celiac test is not recommended for sleep optimization. Genetic tests (HLA) have low predictive value, as many carriers never develop celiac. In summary, the test plays an indirect, potential role: it can uncover a treatable cause of sleep disturbances, but it is not a sleep screening tool.
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