Zöliakie Test: what symptoms are typical?

Typical symptoms of celiac disease are diverse and often involve the digestive tract: chronic diarrhea, bloating, abdominal pain, nausea, weight loss. However, extra-intestinal symptoms such as fatigue, iron-deficiency anemia, skin rash (dermatitis herpetiformis), joint pain, osteoporosis, infertility, and neurological issues can also occur. Many individuals have mild or no symptoms (silent celiac disease). A DNA test for celiac disease (HLA-DQ2/DQ8) can only indicate genetic risk, not the disease itself. A positive result does not guarantee symptoms will develop. Diagnosis always requires medical evaluation: serology (tTG-IgA) and duodenal biopsy. The DNA test is useful for exclusion because nearly all celiac patients carry these genes, but many healthy people do as well. Symptoms alone are insufficient for diagnosis. Evidence for symptoms is strong; for the predictive value of DNA testing it is moderate.