What role does Folsäure play in stress?

Folate (vitamin B9) is essential for one-carbon metabolism, which supports neurotransmitter synthesis (serotonin, dopamine), methylation, and homocysteine regulation. Chronic stress can elevate homocysteine and increase folate demand. Observational studies suggest an inverse association between folate status and stress or depressive symptoms, but the evidence is moderate: randomized controlled trials have not consistently shown that folic acid supplementation reduces stress in well-nourished individuals. Deficiency should be confirmed via blood tests (e.g., serum folate, homocysteine) before supplementing. High-dose folic acid (>1 mg/day) can mask vitamin B12 deficiency, especially in older adults. Thus, folate plays a supportive role in stress physiology, but it is not a standalone stress remedy. A balanced diet rich in folate sources (kale, spinach, legumes) is generally recommended.