Is BDNF useful for longevity?

BDNF (Brain-Derived Neurotrophic Factor) is a protein critical for neuronal survival, synaptic plasticity, and neurogenesis. It is often discussed in the context of brain health and aging. Aerobic exercise is known to increase BDNF levels. Some observational studies link higher BDNF to reduced risk of cognitive decline and dementia. However, direct evidence that BDNF extends human lifespan is limited. Animal studies show BDNF can extend lifespan in mice, but human data are correlational. There are no established optimal ranges for BDNF in blood. Measurement is possible but interpretation is complicated by many factors (time of day, diet, stress). In summary, BDNF is a promising biomarker for healthy aging but not a proven longevity intervention. Evidence: human-moderate.