How are HLA-DQ2 and Müdigkeit related?

The provided knowledge contexts contain no direct information linking HLA-DQ2 and fatigue. HLA-DQ2 is a well-known risk allele for celiac disease, and untreated celiac disease can cause chronic fatigue through malabsorption, inflammation, and micronutrient deficiencies. However, this knowledge comes from clinical medicine, not from the supplied RAG databases. The contexts cover other genes (MC4R, SIRT1) and general nutrigenetics methodology, but not HLA-DQ2. Therefore, the evidence for a direct connection between HLA-DQ2 and fatigue within this data set is unclear. A genetic test for HLA-DQ2 alone does not indicate actual celiac disease or fatigue – additional serological and biopsy confirmation is required. Consumers should not rely solely on genetic markers and should seek medical evaluation for persistent fatigue.