Myths vs facts: COMT and Allergie

Myths vs Facts: COMT and Allergies The COMT gene (catechol-O-methyltransferase) is primarily known for its role in neurotransmitter metabolism, but it also degrades histamine. The common rs4680 (Val158Met) variant reduces enzyme activity, potentially leading to higher tissue histamine levels and worsened allergic responses. **Fact:** Some association studies link the slow COMT variant to a modest increase in allergic rhinitis risk and elevated IgE. However, effect sizes are small and replication is inconsistent. **Myth:** A DNA test for COMT alone cannot diagnose or predict allergies. Environmental triggers, diet, microbiome, and other histamine-related genes (e.g., HNMT) are far more influential. **Bottom line:** COMT is one of many factors. Direct-to-consumer claims about 'allergy genes' are oversimplified. Evidence: human-moderate. Sources: PMID 25646367, 28082741.