How are hsCRP and Sport related?

hsCRP (high-sensitivity C-reactive protein) is a marker of systemic inflammation. Regular physical activity, especially moderate-to-vigorous aerobic exercise, is consistently associated with lower hsCRP levels, indicating reduced chronic inflammation. This relationship is supported by strong human evidence from meta-analyses and intervention trials. Acute intense exercise can transiently raise hsCRP as part of the normal immune response. Genetic variants such as rs1205 in the CRP gene influence baseline CRP levels, but the exercise-induced reduction is independent and typically larger. hsCRP is not a direct measure of fitness but a cardiovascular risk marker; lowering it through exercise contributes to heart disease prevention. Caveats: single measurements can be affected by acute infections or injuries. For personalized interpretation, hsCRP should be evaluated alongside other risk factors and lifestyle habits.