What role does tTG IgA play in Langlebigkeit?

tTG IgA (tissue transglutaminase IgA antibodies) is a specific biomarker for celiac disease, an autoimmune enteropathy that, if untreated, can lead to chronic inflammation, nutrient malabsorption, and increased mortality. In longevity research, tTG IgA plays no direct role as a longevity marker, but indirectly: undiagnosed celiac disease may shorten healthspan through osteoporosis, increased cancer risk, and cardiovascular complications. However, evidence for a causal effect on maximum lifespan is limited. Most studies show a moderate increase in all-cause mortality in untreated celiac disease, but the effect size is modest. In healthy individuals without celiac disease, tTG IgA has no proven relevance to longevity. MyBody-X tests are not diagnostic; a positive tTG IgA result requires medical follow-up (duodenal biopsy). Caveat: a negative test does not fully rule out celiac disease, especially in IgA deficiency. Evidence grade: human-moderate (celiac mortality data).