What role does Zink play in allergy?

A positive HLA-DQA1 genotype (e.g., DQ2.5 or DQ8) is necessary but not sufficient for celiac disease. About 30–40% of healthy individuals carry this variant without ever developing celiac. The test indicates increased risk, not disease. Definitive diagnosis requires positive serology (tTG-IgA) and duodenal biopsy with histological damage. Do not start a gluten-free diet before medical confirmation, as it can obscure diagnosis. Direct-to-consumer tests often overstate the clinical meaning of such gene variants. Evidence is mechanistic (gene association), not diagnostic. Caveat: Do not make medical decisions based solely on this result.