Can VKORC1 help with longevity?

The question of whether VKORC1 can aid longevity is not supported by current evidence. VKORC1 encodes vitamin K epoxide reductase, a key enzyme in the vitamin K cycle primarily known for its role in blood coagulation and warfarin sensitivity. None of the provided contexts mention VKORC1; the genes discussed (FOXO3, VDR, PPARGC1A, etc.) have some associations with metabolism, inflammation, or longevity, but VKORC1 does not. There are no robust GWAS or interventional studies linking VKORC1 variants directly to lifespan. While vitamin K status influences bone and vascular health, the genetic regulation via VKORC1 is complex and not validated as a longevity marker. Consumer DNA tests that include VKORC1 typically focus on drug response, not aging. Using this gene alone to predict or enhance longevity is speculative and lacks evidence. Established lifestyle factors—diet, exercise, sleep—remain far more impactful.