Risks and limits of MTHFR Basis

The MTHFR Basic test analyzes common variants (C677T, A1298C) in the MTHFR gene, which is involved in folate metabolism. However, the clinical significance of these variants is limited. Most individuals with these variants are asymptomatic. A positive result may lead to unnecessary anxiety or costly supplements (e.g., methylfolate) without proven benefit. The German Nutrition Society does not recommend routine MTHFR testing. Interpretation is complex: heterozygous or homozygous variants are common (up to 40% of the population) and usually benign. The test does not replace medical evaluation for actual symptoms. Major risks include overdiagnosis, self-medication, and false reassurance. Evidence: mostly marketing, weak clinical validation. Sources: none provided in context.