What role does SHBG play in menopause?

SHBG (sex hormone-binding globulin) plays a role in menopause by regulating the bioavailability of sex hormones. As estrogen declines during menopause, SHBG levels often decrease, leading to a relative increase in free testosterone. This shift has been associated with symptoms such as hair loss, acne, or mood changes. However, SHBG is also influenced by insulin, thyroid function, liver health, and body weight. The evidence from the provided knowledge context is weak – no direct studies or sources on SHBG in menopause are included. Therefore, caution is warranted: a single SHBG value from a home test is not diagnostic and should not be interpreted in isolation. The clinical relevance is moderate, but individual factors are critical. Evidence: unclear due to lack of specific sources.