How are HLA-DQ2 and Langlebigkeit related?

HLA-DQ2 is a genetic marker strongly associated with celiac disease, an autoimmune condition triggered by gluten. Untreated celiac disease can lead to chronic inflammation, nutrient malabsorption, and increased risk for certain cancers, potentially reducing lifespan. However, there is no direct, robust evidence that HLA-DQ2 alone influences longevity. Most studies linking HLA-DQ2 to longevity are indirect, focusing on the health consequences of untreated celiac disease. With strict adherence to a gluten-free diet, individuals with celiac disease have a normal life expectancy. In the general population, HLA-DQ2 is common (about 25–30% of Europeans carry it), but only a small fraction develop celiac disease. Thus, the effect on longevity at the population level is small. A DNA test for HLA-DQ2 can indicate increased risk for celiac disease, but cannot predict individual lifespan. Evidence is human-observational, not directly on longevity. Caution is warranted against overblown claims from direct-to-consumer tests.