What to watch with HLA-DQ2 and longevity?

HLA-DQ2 is a well-established genetic risk factor for celiac disease, an autoimmune condition triggered by gluten. Untreated celiac disease can lead to chronic inflammation, malabsorption, and increased mortality, potentially impacting longevity. However, the direct link between HLA-DQ2 and lifespan is not supported by the provided context. Most individuals with HLA-DQ2 never develop celiac disease; penetrance is low. What to watch for: symptoms like fatigue, diarrhea, bloating, or dermatitis herpetiformis. If symptoms appear, serological testing (tTG-IgA) and endoscopic biopsy are needed for diagnosis. A positive DNA result alone does not warrant a gluten-free diet without clinical confirmation. The evidence for using HLA-DQ2 as a longevity predictor is weak. Instead, focus on evidence-based longevity factors: balanced diet, regular exercise, avoiding smoking, and managing stress. Consumer DNA tests like MyBody-X do not provide validated longevity risk assessment for this marker.