Evidence check: Cardio Risk Check in the context of Sport

Evidence for cardio risk checks in sport is mixed. Some markers like rs4149056 (SLCO1B1) have strong GWAS support for statin myopathy risk, but no direct proof that knowing it improves athletic outcomes. Others (rs1205 CRP, rs1800566 NQO1) are mechanistic or unclear – they explain minimal variance. The MTNR1B variant (rs10830963) affects melatonin and glucose, with indirect, small effects on cortisol and recovery. For athletes, lifestyle, training load, and nutrition dominate. A DNA test alone cannot replace clinical risk assessment (lipid panel, BP, ECG). Caveat: never stop statins without a doctor; single SNP effects are typically small. Evidence: mixed – some GWAS, some mechanistic, some unclear.