Evidence check: COMT in the context of Langlebigkeit

COMT (catechol-O-methyltransferase) is frequently discussed in the context of cognitive performance, stress regulation, and neurotransmitter metabolism. The common rs4680 (Val158Met) polymorphism affects enzyme activity: Val carriers have higher activity, Met carriers lower. Some studies suggest links to cognitive aging and stress resilience, which could indirectly influence longevity. However, evidence is mostly mechanistic and based on observational studies; direct associations with lifespan are weak and inconsistent. Consumer DNA tests often include COMT, but clinical utility for longevity is limited. Lifestyle factors (diet, exercise, sleep) have a far greater impact. Relying solely on genetic assessment without considering environment and epigenetics is misleading. Safety note: Do not make medical decisions based on COMT alone.