Evidence check: CLOCK in the context of Müdigkeit

The CLOCK gene is a core component of the circadian clock. Certain polymorphisms (e.g., rs1801260) have been linked to diurnal preference, sleep duration, and fatigue in GWAS. However, effect sizes are small, and findings are often not replicated. Fatigue is highly multifactorial, involving sleep quality, stress, nutrition, and medical conditions. Therefore, a consumer DNA test for CLOCK variants cannot reliably predict or explain fatigue. Evidence is limited to genetic association studies (GWAS) with modest odds ratios. Clinical assessment and lifestyle interventions remain the primary approach. If you have persistent fatigue, consult a physician rather than relying on genetic results.